GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs965513 | 1 | rs1561962 | chr9:100546219 | PLCE1 | chr10:95753746-96088146:+ | 0.28 | 6.42 | 3.32E-10 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs1588635 | chr9:100537802 | EML5 | chr14:89081205-89259157:- | 0.31 | 6.79 | 3.31E-11 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs1588635 | chr9:100537802 | EPDR1 | chr7:37960163-37991539:+ | 0.31 | 6.57 | 1.32E-10 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs1588635 | chr9:100537802 | LRRC42 | chr1:54412037-54433839:+ | -0.24 | -6.02 | 3.56E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs1588635 | chr9:100537802 | NKX6-1 | chr4:85414436-85419387:- | 0.51 | 8.51 | 2.31E-16 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs1588635 | chr9:100537802 | PLCE1 | chr10:95753746-96088146:+ | 0.29 | 6.38 | 4.1E-10 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs6600671 | 1 | rs1591882 | chr1:121183313 | NBPF14 | chr1:148003643-148346791:- | 0.41 | 9.86 | 5.29E-21 | Hip geometry |
| THCA | trans | rs853679 | 1 | rs1679709 | chr6:28228342 | BTN3A2 | chr6:26365398-26378546:+ | 0.5 | 9.8 | 9.06E-21 | Depression |
| THCA | trans | rs853679 | 1 | rs1679732 | chr6:28221264 | BTN3A2 | chr6:26365398-26378546:+ | 0.51 | 9.93 | 3.09E-21 | Depression |
| THCA | trans | rs16958445 | 1 | rs16958445 | chr15:74176557 | AGPAT1 | chr6:32135990-32145842:- | 0.66 | 6.3 | 6.94E-10 | Exfoliation glaucoma or exfoliation syndrome |
| THCA | trans | rs853679 | 1 | rs1778508 | chr6:28229881 | BTN3A2 | chr6:26365398-26378546:+ | 0.49 | 9.66 | 2.76E-20 | Depression |
| THCA | trans | rs853679 | 1 | rs1778511 | chr6:28229411 | BTN3A2 | chr6:26365398-26378546:+ | 0.5 | 9.8 | 9.06E-21 | Depression |
| THCA | trans | rs1814175 | 1 | rs1814175 | chr11:49559172 | FOLH1B | chr11:89392465-89431885:+ | -0.35 | -6.41 | 3.48E-10 | Height |
| THCA | trans | rs6600671 | 1 | rs1832558 | chr1:121177380 | NBPF14 | chr1:148003643-148346791:- | 0.4 | 9.31 | 4.82E-19 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs1856572 | chr1:121169579 | NBPF14 | chr1:148003643-148346791:- | 0.44 | 10.31 | 1.2E-22 | Hip geometry |